The aim of this study was to examine the potential preventive properties of white tea extract, a potent antioxidant, against cisplatin-induced damage to the cerebral cortex. Thirty-six male Sprague Dawley rats were distributed into healthy control, sham, (only White tea), cisplatin, and cisplatin+White tea groups. After white tea alone was administered per oral at a rate of 1.5 % for twelve days in experimental group rats only a single dose of 7 mg / kg cisplatin (CIS) was be administered intraperitoneally. We observed that oedematous areas in degenerative neurons in the cisplatin administration group. However, we monitored that degenerative neurons and oedematous were decreased in the white tea treatment group compared to the cisplatin group. In addition, we found increased in MDA and Caspase-3 levels in the Cisplatin application group compared to the control group (p<0.05). On the contrary, we found decreased in GSH levels in the Cisplatin application group compared to the control group (p<0.05). On the other hand, we found decreased in MDA, Caspase-3 levels and increased GSH levels in the Cisplatin application group compared to the control group (p<0.05). White tea has shown therapeutic effects on cisplatin-induced cerebral cortex injury via decreased oxidative stress and Caspase-3 expression.

KEY WORDS: Caspase-3; Cisplatin; GSH; MDA; White tea.

BATCIK, O.E.; MERCANTEPE, T. & YILMAZ, A. Investigation of the effects of white tea against cerebral cortex damage induced by cisplatin. Int. J. Morphol., 42(5):1248-1253, 2024.