Zarina Shulgau, Shynggys Sergazy, Tatyana Krivoruchko, Nuriya Kenzhebayeva, Bayan Sagindykova & Alexandr Gulyayev

The aim of the study was to evaluate the osteoprotective properties of RNA-containing drug Osteochondrin S on rats with experimental model of osteoporosis. Osteochondrin S contains yeast RNA and RNA of connective tissue of cattle. In order to model osteoporosis in rats bilateral ovariectomy was used. Rats were divided into 3 groups: 1 - ovariectomized rats receiving Osteochondrin S; 2 - ovariectomized rats receiving saline; 3 - sham-ovariectomized rats. Rats in group 1 received Osteochondrin S, Group 2 - physiological saline three times a week for 12 weeks. Based on morphological data and on the results of densitometry, Osteochondrin S prevents a decrease in bone density, i.e. exhibits osteoprotective properties. Under the condition of lack of sex hormones in rats Osteochondrin S reduces reactive oxygen species in blood plasma and limits the degree of decrease in antioxidant capacity of blood plasma.

KEY WORDS: Ovariectomy; Osteoporosis; Osteochondrin S; RNA extracts.

SHULGAU, Z.; SERGAZY, S.; KRIVORUCHKO, T.; KENZHEBAYEVA, N.; SAGINDYKOVA, B. & GULYAYEV, A. Osteoprotective properties of RNA-containing drug Osteochondrin S on the model of insufficiency of sex hormones in rats. Int. J. Morphol., 35(4):1233-1238, 2017.