Sergio Sotelo; Carlos Manterola & Luis Grande

Since gastric cancer is the 3rd leading cause of death from cancer in Chile, and there are screening strategies consisting of screening for preneoplastic lesions of the gastric mucosa, it is important to know certain genetic and molecular aspects that can be applied in optimizing these strategies for higher risk groups. The aim of this manuscript was to review the current evidence on the aforementioned aspects, and on the immunohistochemistry of 4 markers (p53, CDX2, MUC2 and S100A9) in normal gastric mucosa and in its preneoplastic lesions.

KEY WORDS: "Stomach Neoplasms"[Mesh]; "Stomach Neoplasms/pathology"[Mesh]; "Precancerous Conditions"[Mesh]; "Gastric Mucosa"[Mesh]; "Mass Screening"[Mesh]; "Genes, p53"[Mesh]; "CDX2 Transcription Factor"[Mesh]; "MUC2 protein, human" [Supplementary Concept].

SOTELO, S.; MANTEROLA, C. & GRANDE, L. Histological, genetic and molecular aspects of preneoplastic lesions of the gastric mucosa. Int. J. Morphol., 41(2):491-500, 2023.