srin Nalbant;Ugur Dalaman; Kadir Gök; Özden Bedre Duygu; Nazmi Yaras; Servet Kavak

It is known that diabetes mellitus has late complications, including microvascular and macrovascular diseases. Diabetes can affect bones through biochemical markers of bone structure, density, and turnover. This study aimed to biomechanically investigate the bone-protective effects of angiotensin 1–7 (Ang 1-7), one of the active peptides in the renin-angiotensin system, in rats with diabetes. Thirty male Wistar albino rats, three months old and weighing 250–300 g, were divided into four groups: diabetes, Ang 1– 7, diabetes plus Ang 1–7, and control. One month later, diabetes developed in rats; the rats were sacrificed, and their right femur was removed. Three-point bending biomechanical tests were performed on the femurs. The diabetic group had significantly higher bone fragility than the other groups (Pr >.05). Bone fragility was lower, and bone flexibility was higher in the Ang 1-7 groups (Pr>F value 0.05). As a result of our study, the effect of Ang 1–7 on the bones of rats with diabetes was investigated biomechanically. Ang 1–7 has a protective impact on the bones of rats with diabetes.

KEY WORDS: Diabetes mellitus; Angiotensin 1-7; Three point bending test; Bone; Renin-angiotensin system.

NALBANT, A.; DALAMAN, U.; GÖK, K.; BEDRE, DUYGU, Ö.; YARAS, N. & KAVAK, S. Biomechanical effects of angiotensin 1- 7 in diabetes rats femur. Int. J. Morphol., 41(3):894-900, 2023.