Rodríguez, Héctor; Cortés-Chau, Felipe; Cortés-Pino, Felipe; Aguirre, Pablo; Bravo, Gonzalo; Gallegos, Iván; Arriaza, Camilo; Cuéllar, Caroll; Aguayo, Francisco & Espinoza-Navarro, Omar

The different pathologies of the prostate, involve the presence of a new microenvironment where inflammatory cells are actively recruited. This research explores the presence of mast cells and eosinophils associated with age and the evaluation of prostate cancer progress (Gleason Index). Forty two biopsies of anonymized patients, with confirmed prostate cancer, were used for histological analysis for eosinophils and mast cells and subsequent determination of Gleason index according to age. The results of the histological analyzes show the presence of eosinophils and mast cells in prostate biopsies with confirmed cancer. In the multiple correlation studies, a high correlation was observed between the presence of lymphocytes and the age of the patient diagnosed with prostate cancer, same correlation was observed between the patient's age and higher Gleason Index (Pearson and Spearman p< 0.05). It is concluded that in prostate biopsies from Chilean patients with confirmed cancer, eosinophilia and tissue mastocytosis were observed. Correlation analyzes show a direct correlation between older patients, higher Gleason index and presence of mast cell. Regarding eosinophilia, only a correlation between age and Gleason index was observed Further studies are suggested to determine that the presence of eosinophils and mast cells can be used as early bioindicators of prostate cancer.

KEY WORDS: Prostate bioindicators; Early diagnostic; Cancer; Cellular microenvironment.

RODRÍGUEZ, H.; CORTÉS-CHAU, F.; CORTÉS-PINO, F.; AGUIRRE, P.; BRAVO, G.; GALLEGOS, I.; ARRIAZA, C.; CUÉLLAR, C.; AGUAYO, F. & ESPINOZA-NAVARRO, O. Morphological changes of the cellularity in the prostatic gland from patients with confirmed cancer: Gleason level and presence of eosinophils and mast cells: Cellular bioindicators. Int. J. Morphol., 38(4):882-887, 2020.