This study aimed to evaluate the potential antioxidant, anti-inflammatory, antidepressant, and anxiolytic effects of Actinidia deliciosa extract (ADE) in comparison to silymarin (SILY) in mitigating carbon tetrachloride (CCl )-induced hepatotoxicity 4 and behavioral changes in male albino rats. A total of forty-two male albino rats were randomly divided into seven groups: control, ADE 0.5 g/kg, ADE 1.0 g/kg, CCl only, SILY + CCl , ADE 0.5 + CCl , and ADE 1.0 + CCl4 . The administration of ADE significantly 4444 reduced serum liver enzyme levels, improved antioxidant markers, and alleviated behavioral abnormalities. ADE also downregulated the hepatic expression of CYP2E1 and Type I collagen, suggesting its potential hepatoprotective and neuroprotective properties. These findings indicate that ADE may serve as a promising alternative to silymarin in protecting against chemical-induced liver damage.
KEY WORDS: Actinidia deliciosa; Antioxidant; Hepatotoxicity; CYP2E1; Anxiolytic; Depression; Liver injury.
MOHAMMEDSALEH, Z. M. Protective effects of Actinidia deliciosa extract and silymarin on CCl4 -induced hepatotoxicity and behavioral alterations in male albino rats. Int. J. Morphol., 43(5):1714-1725, 2025.
