Amiodarone (AMD) is categorized as an antiarrhythmic. Serious side effects of the treatment included a significant reduction in renal function. Extract from Ginkgo biloba leaves (GBL) has been shown to be an effective free radical scavenger and antioxidant. The purpose of this study was to evaluate the effect of GBL extract on nephrotoxicity brought on by AMD. Forty male rats were divided into four groups. Control in Group I. Group II got GBL extract. On the 21st day, AMD group received an intraperitoneal (i.p.) injection of AMD. In GBL plus AMD group, rats received GBL for 21 days before receiving AMD. After four weeks, the rats were sacrificed, and their kidneys were removed for histological, ultrastructural, N-acetyl-beta-D glycosaminidase (NAG) levels, renal function markers like serum urea, creatinine, protein excretion rate, inflammatory cytokines and oxidative stress markers were determined. AMD- induced kidney damage in rats may be brought on by oxidative stress producing significant renal cytotoxicity, as evidenced by biochemical, histopathological, and electron microscopy investigations. After administering GBL extract to AMD group, every parameter that was looked at through this study was significantly improved. According to the current study's findings, GBL extract reduced AMD-induced nephrotoxicity by acting as an antioxidant.

KEY WORDS: Amiodarone; Nephrotoxicity; Ginkgo biloba; Histopathology; Renal function markers; NAG.