Rasha M. Salama & Reham E. Aboukhalil

4-Methylbenzylidene camphor (4-MBC) is a photo-absorbing UV filter prevalently used in cosmetics, which can be absorbed into circulation and cause systemic effects. It is known to act as an endocrine disruptor. Resveratrol is a well characterized antioxidants found in some fruits and plants. This study considers 4-MBC’s potential effects on thyroid gland proliferation, inflammation and apoptosis and hormone levels and evaluated the expected protective potential of resveratrol. Thirty adult male albino rats were divided into control, treated (4-MBC), and protected (4-MBC + Resveratrol) groups. Treatments were administered for 35 days. We assessed serum T3, T4, and TNF-α levels, alongside histological and immunohistochemical (Caspase-3) analyses. 4-MBC treatment significantly reduced thyroid hormones (T3, T4) and increased inflammatory (TNF-α) and apoptotic markers (Caspase-3), causing follicular distortion. Co-administration of resveratrol significantly reversed these effects, restoring hormonal levels to near-normal values and preserving thyroid histology. 4-MBC induces thyroid dysfunction, inflammation, and apoptosis. Resveratrol effectively mitigates these alterations, suggesting its potential as a protective agent against environmental endocrine disruptors.

KEY WORDS: 4-MBC; Resveratrol; T3; T4; TNF-a; Caspase-3.

SALAMA, R. M. & ABOUKHALIL, R. E. Evaluation of resveratrol protective effects against 4-methylbenzylidene camphor induced thyroid toxicity in albino rats. Int. J. Morphol., 44(3):766-772, ,2026.