Qiang Xu; Hao Weng; Liang Zhu; Mingxian Wu & Zhu Mei

Bone defects are a common orthopedic trauma in clinical practice. Limb amputation has been used in the past, but its disadvantages are evident. Autogenous bones are widely recognized in modern medicine as the gold standard for bone graft fusion due to its strong osteoinductive properties, good osteogenicity, and low cost. Seventy patients diagnosed with distal infectious bone defect (DIBD) after tibial fracture (TF) were randomly assigned to an observation (Obs) group (n = 35) and a control (Ctrl) group (n = 35). Bone marrow enriched bone graft surgery (BME-BGS) and traditional bone graft surgery (T-BGS) were performed in the Obs and Ctrl groups, respectively, for comparison. The time for disappearance of the fracture line (T-DFL) and the time for fracture healing (T-FH) were considerably shorter in the Obs group (P<0.05). The postoperative callus formation score (CFS), bone morphogenetic protein (BMP), transforming growth factor (TGF)-β, and alkaline fibroblast growth factor (AFGF) levels in the Obs group were sharply higher (P<0.05). Furthermore, treatment effectiveness rate (TER) in Obs group was considerably higher (P<0.05). Meanwhile, incidence of complications (IOC) in Obs group (11.43 %) was higher to 20 % in Ctrl group (P<0.05). Compared with T-BGS, the BME-BGS can effectively shorten the T-DFL in patients with DIBD after TF, promote the secretion of osteogenic induction factors and callus formation, and effectively improve the efficacy of fracture end healing, with clinical safety.

KEY WORDS: Bone defect; Tibial fracture; Callus formation; Bone marrow enriched bone graft surgery; Bone growth factor.

XU, Q.; WENG, H.; ZHU, L.; WU, M. & MEI, Z. Influence of bone marrow enriched bone grafting versus traditional bone grafting in callus formation and bone growth factors of patients with tibial fracture and bone defect. Int. J. Morphol., 43(3):759-765, 2025.