Paulina Pizarro; Constanza Ralph; Ignacio Roa & Mariana Rojas

Congenital Uterine Malformations (CUD) are generally asymptomatic, benign and incidentally diagnosed. In order to describe the different types of CUD, it is necessary to understand its embryonic development, emphasizing at the same time the importance of the paramesonephric ducts, structures that later in development will give rise to the uterine tubes and the utero-vaginal duct. The objectives of the present study were to analyze basic aspects of the normal and pathological development of the female genital tract during embryonic/fetal development, correlating them with the histological evaluation, and relating such aspects to possible future uterine pathologies that girls could experience from the beginning. of puberty. A human fetus of approximately 8 weeks gestational age was studied. Four mouse fetuses 15 days post-coitus were also used as an animal model, of which 2 corresponded to female individuals and 2 to male individuals. The biological samples were fixed in 10% Formalin and subsequently processed using routine histological techniques and staining with Hematoxylin-Eosin. Most paramesonephric malformations mainly affect the uterus, and are characterized by the manifestation of deficits, either in the development, fusion orcanalizationoftheparamesonephricducts. Variousdevelopmentalmechanisms,suchascellproliferation,apoptosisandepithelial-mesenchymal transformations, are essential for the normal development of the uterine tubes and the uterus. Paramesonephric malformations are generally manifested during adolescence and are usually accompanied by symptoms including pelvic pain and primary amenorrhea.

KEY WORDS: Paramesonephric ducts; Congenital uterine malformations; Müllerian anomalies.

PIZARRO, P.; RALPH, C.; ROA, I. & ROJAS, M. Congenital uterine malformations. Int. J. Morphol., 43(3):941-947, 2025.