Heinrich August Wrisberg (Fig. 1) was born on 28 July 1736 in Sankt Andreasberg, Germany, a small town near Göttingen. He studied medicine at the Georg-August- University of Göttingen (1757) and he worked as prosector in the Anatomical Institute of the University of Göttingen from 1762 to 1764 (Tubbs et al., 2014). In 1764 he obtained his MD degree from the University of Göttingen with a thesis on the phrenic nerve titled “De Respiratione Prima Nervo Phrenico et Calore Animali“. Firstly devoted to the study of female reproductive system and obstetrics, he subsequently performed very important studies on respiration, trigeminal nerve, nerves of the abdomen and arm and embryology. Wrisberg took over from his master Johan Georg Roederer (1726–1763), who in turn took the chair of Albrecht von Haller, the 2nd Professor of Anatomy at the young University of Göttingen (Tubbs et al., 2014). Wrisberg was an excellent neuroanatomist and is also renowned for his studies on the cuneiform cartilages of the larynx (cartilages of Wrisberg), the ganglion of the superficial cardiac plexus (Wrisberg's ganglion), the lateral meniscus of the knee and the posterior meniscofemoral ligament (ligament of Wrisberg). Among his numerous anatomical discoveries, the fibers connecting the motor and the sensory roots of the trigeminal nerve (Wrisberg's lingula) must be mentioned, as well as his important scientific contributions to the anatomy of the nervous system; these include the original descriptions of the nervus intermedius, as well as a branch of the brachial plexus supplying the skin of the medial side of the arm, the medial brachial cutaneous nerve (Tubbs et al., 2014). In 1777 Wrisberg firstly described his most important discovery concerning the respiratory system: an unknown anatomical variant of the lung consisting in an accessory lobe directly connected to the azygos vein. According to Collins (1875),“The observations made by Wrisberg were chiefly directed to the condition of the vena azygos, which passed through an accessory fissure in the lung above the right bronchus, isolating a lobe which passed behind the vein for some distance. The azygos vein terminated in the highest part of the vena cava”. This was, in the available literature, the first description of a new lung’s anatomical variant consisting  in an accessory lobe in which the right lung presents a very rare and congenital variation represented by an upper and medial additional lobe, the so-called “azygos lobe”. Other authors have described such variant which is considered nowadays an interesting and “curious” pulmonary lobe (Chabot-Naud et al., 2011; Branca et al., 2023). As it has been masterfully reported by Tubbs et al. (2014): “Wrisberg was an anatomist, a physician, a teacher and a researcher. He contributed to many different fields of science and worked extensively until his death on 29 March 1808 in Göttingen. Wrisberg's name lives on via several anatomical terms. It is the contribution of such early pioneers in Anatomy such as Wrisberg , on which we base our current understanding of the human form”.